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Nanoscale protein aggregates, including those of α-synuclein, β-amyloid, and tau, play a central role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. However, detecting and quantifying these aggregates in biofluids and postmortem brain tissue remains a major analytical challenge due to their low abundance and small size.

In this webinar co-hosted with Inside Precision Medicine, our expert speakers Zengjie Xia, PhD, Dorothea Böken, and Lindsey Marsh, PhD, will share results from efforts to develop and validate ultrasensitive single-molecule array (Simoa^®) assays for detecting and quantifying protein aggregates with high sensitivity and specificity. These assays achieve detection limits in the low picomolar range and allow for the quantification of aggregates with disease-relevant post-translational modifications, such as truncated α-synuclein and phosphorylated tau. During the webinar, you’ll learn about the use of silica-nanoparticle calibrators for aggregate quantification, and how they were applied to postmortem brain homogenates and blood-based diagnostics. They will also discuss the potential of these methods for biomarker discovery and early diagnosis of neurodegenerative diseases. 

A Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelists.

Speaker Info:

Zengjie Xia, PhD
Research Fellow
UK Dementia Research Institute
University College London

Dorothea Böken
PhD Student
University of Cambridge
UK Dementia Research Institute

Lindsey Marsh, PhD
Senior Field Application Scientist
Quanterix

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