p-Tau 217 (Simoa® ALZpath) Assay

For researchers in the field of neurology, detecting phosphorylated Tau 217 (p-Tau 217) in plasma or cerebrospinal fluid (CSF) is crucial in advancing studies from discovery to clinical applications. The Quanterix Simoa® ALZpath p-Tau 217 Assay offers an ultrasensitive, reliable solution to measure p-Tau 217 levels, providing insights into neurodegenerative diseases like Alzheimer’s.

What is the Quanterix Simoa® ALZpath p-Tau 217 Assay?

The Quanterix Simoa® ALZpath p-Tau 217 Assay is an ultrasensitive laboratory assay test designed to accurately measure p-Tau 217 levels in plasma, or cerebrospinal fluid (CSF) samples. This p-Tau 217 assay is performed using Quanterix’s Simoa® platform, a digital immunoassay technology that detects and measures low levels of biomarkers.

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Benefits of using the Simoa® ALZpath p-Tau 217 Assay

• Ultrasensitive Detection: Highly sensitive and specific detection of p-Tau 217, allowing for early and accurate detection of neurodegenerative diseases in research applications
• Compatibility with Multiple Sample Types: Compatible with a range of sample types, including blood and CSF, making it a versatile p-Tau 217 assay
• Ideal for Neurology: Supports the study of Alzheimer’s disease and other neurodegenerative conditions, facilitating early detection and monitoring of disease progression

The Role of Tau in Neurodegenerative Diseases

Tau is a critical protein that stabilizes microtubules within neurons, but it also plays a pivotal role in neurodegenerative diseases when it becomes dysfunctional. Although primarily found in neurons, tau is also present at lower levels in astrocytes and oligodendrocytes. It comprises six isoforms, ranging from 48,000 to 67,000 daltons, depending on the specific isoform.

In Alzheimer’s disease and other neurodegenerative conditions, tau can become abnormally phosphorylated and aggregate into filament bundles, leading to neuronal damage and cognitive decline. The presence of elevated tau levels in cerebrospinal fluid (CSF) is a known hallmark of brain injury and neurodegeneration.

p-Tau 217: A Key Biomarker in Alzheimer’s Disease

Threonine 217 is one of the critical phosphorylation sites in tau, making p-Tau 217 a significant biomarker for Alzheimer’s disease. Research shows that p-Tau 217 levels in cerebrospinal fluid (CSF) and blood are significantly elevated in patients with Alzheimer’s, even in the early stages, indicating its potential as a valuable diagnostic and prognostic tool. Furthermore, studies have shown that p-Tau 217 can help differentiate Alzheimer’s disease from other forms of dementia, such as Lewy body dementia and frontotemporal dementia.

Applications and Intended Use

The Quanterix Simoa® ALZpath p-Tau 217 assay is validated for use in discovery and diagnostic research applications. The Simoa® ALZpath p-Tau 217 assay targets the proline-rich region of the Tau protein, which is highly conserved amongst the tau isoforms.

• Research on Neurodegenerative Diseases: By measuring phosphorylated tau protein levels in the blood, researchers can gain insights into the role of p-Tau 217 in the disease process and develop new diagnostics and neuro-prognostics for these debilitating diseases.
• Drug Discovery: Identify and screen promising drug candidates for further development and testing.
• Biomarker Discovery and Validation: Researchers can use the Simoa® ALZpath p-Tau 217 assay to validate emerging biomarkers, providing researchers with a reliable and accurate tool for biomarker discovery workflows.

Compatible Instruments

The ALZpath p-Tau 217 assay is available for use on the Quanterix HD-X™ Automated Immunoassay Analyzer, which offers automated sample processing and high-throughput capabilities.

Simoa® ALZpath p-Tau-217 Advantage PLUS Assay Performance

Analytical LLOQ: 0.00326 pg/mL
Functional LLOQ: 0.00978 pg/mL
Functional ULOQ: 30 pg/mL
LOD: 0.0008 pg/mL; range 0.0003-0.0021 pg/mL
Dynamic Range: 0-30 pg/mL
Tests per kit: 96

Kit Contents

The assay kit includes all necessary reagents and controls to perform 96 tests, making it easy to use and compatible with various sample types.

Related Information

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Quanterix HD-X™ Automated Immunoassay Analyzer