MCP-1 (RAT)

Monocyte chemoattractant protein-1 (MCP-1, also called chemokine (C-C motif) ligand 2, CCL2) is a chemokine that recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. MCP-1 is implicated in pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. MCP-1 is also involved in the neuroinflammatory processes in various CNS diseases characterized by neuronal degeneration, including Alzheimer’s disease and traumatic brain injury.