IP-10 (MOUSE) Assay

IFN-γ-inducible protein 10 (IP-10, CXCL10) is a 10 kDa chemokine secreted from cells stimulated with type I and II interferons (IFNs) and lipopolysaccharide (LPS). IP- 10 is constitutively expressed at low levels in thymic, splenic, and lymph node stroma. Elevated levels of IP-10 protein have been found in the cerebral spinal fluid in patients with viral meningitis and multiple sclerosis. In these diseases, levels of IP-10 correlate with the tissue infiltration of T lymphocytes, suggesting that IP-10 plays an important role in the recruitment of T cells to sites of tissue inflammation.