IL-8 (NON-HUMAN PRIMATE)

Interleukin 8 (IL-8) is a cytokine of 72 amino acids (molecular weight 8 kDa) whose primary role is induction of chemotaxis in neutrophils, basophils, and T-cells, causing them to migrate to the site of infection. IL-8 also induces phagocytosis by the target cells. IL-8 is secreted by cells involved in the immune response to antigens, typically starting with macrophages, which release IL-8 to recruit other cells. Secretion of IL-8 is increased by oxidant stress, which thereby cause the recruitment of inflammatory cells, inducing a further increase in oxidant stress mediators, making it a key parameter in localized inflammation. IL-8 elevation has been associated with a range of clinical conditions, including psoriasis, chronic hepatitis C, and thyroid disease. IL-8 has recently been identified as a potential therapeutic target in inflammatory diseases.