Current Alzheimer Research | February 18, 2021

Hall JR, Johnson LA, Peterson M, Julovich D, Como T and O’Bryant SE

Curr Alzheimer Res. 2021

DOI: 10.2174/1567205018666210219105949

Abstract:

Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

This study was performed using the Quanterix HD-1 Analyzer.