MISSED CONNECTIONS: THE STRUCTURAL AND BIOCHEMICAL MARKERS OF NEURODEGENERATION

A beautifully illustrated visual overview of 5 of the most common disorders affecting the brain and the protein biomarkers associated with their diagnosis, progression, and treatment.

Below is an introduction to the poster titled – Missed Connections: The Structural and Biochemical Markers of Neurodegeneration
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Highly specialized, neurons receive, propagate, and transmit electrical and chemical signals to control motor actions, regulate body functions, and interpret and respond to external stimuli. The ability to perceive and interact with the world hinges on neuronal function–and, naturally, physical damage to neurons is a core cause of many neurological pathologies. Understanding the extent of this damage is the first step to repairing the destruction that has been wrought, and scientists use the presence of biomarker molecules, released when cellular or tissue integrity has been compromised, to detect and gauge neurological injury

Biomarker Abbreviations:

• Aβ1-42: Amyloid beta peptide fragment containing amino acids 1-42
• CCL11: C-C motif chemokine 11
• GFAP: Glial fi brillary acidic protein
• JC Virus: John Cunningham Virus
• MBP: Myelin basic protein
• NF-H: Neurofilament heavy chain
• NF-L: Neurofilament light chain
• UCH-L1: Ubiquitin C-terminal hydrolase-L1

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