Simoa® Technology

Measure biomarkers at lower levels than ever before.

From discovery to diagnostics, Quanterix’s ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease.

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Measure biomarkers at lower levels than ever before

Simoa® Bead Technology

Quanterix’ digital biomarker detection technology, Simoa®, is changing the way in which the biology of health and disease is studied by giving researchers the ability to examine critical proteins and nucleic acids, at ultra low – even baseline – levels, in most common sample types.

  • First of its kind detection capabilities
  • Detect biomarkers at femtogram levels
  • See results in record time
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How it works

A high-level look at a Simoa Bead-based assay, from development to data analysis.

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Paramagnetic particles coupled with antibodies designed to bind to specific targets are added to the sample.

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Detection antibodies – capable of generating fluorescent product – are added.

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The objective is to form an immunocomplex consisting of the bead, bound protein, and detection antibody.

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At low concentrations, each bead will contain one bound protein, or none.

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The sample is loaded into arrays, in the Simoa disc, consisting of more than 200,000 microwells – each large enough to hold one bead.

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Enzymatic signal amplification with fluorescent substrate, fluorescence imaging and data reduction.

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Data analysis – results can be viewed and analyzed on the board or exported to commonly used software packages or LIMS systems.

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Measure biomarkers at lower levels than ever before

Simoa® Planar Array Technology

An incredibly simple, flexible, robust, and ultra-sensitive immunoassay platform for measuring up to 10-plex biomarkers. Its unique capabilities are designed specifically to address many of today’s unmet needs in immuno-oncology and other research areas.

  • Proprietary, high-precision, digital nanofluidic antibody deposition
  • Reaction kinetics optimized by fluid dynamics
  • Optimized image quality and dynamic range
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How it works

A high level look at a Simoa Planar Array assay, from initiation to imaging.

1

96-well plates are spotted at the factory with the target analyte(s) of interest

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Diluted samples and standards added to each well and the plates are to create a unique surface chemistry and “vortex” effect

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Biotinylated detection antibodies are added to form the other half of the immunocomplex “sandwich”

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High sensitivity HRP enzyme-conjugated streptavidin is added in between additional shake cycles.

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Finally, a chemiluminescent substrate is added just prior to ultra-sensitive CCD camera imaging, in order to measure the signal intensity produced by each spot.

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HD-X™ Automated Immunoassay Analyzer

Introducing the world’s most sensitive, fully automated immunoassay platform with multiplexing and custom assay capability.

HD-X™ Automated Immunoassay Analyzer tab thumbnail

1000x

Up to 1000x greater sensitivity

4 in 1

Up to 4 biomarkers in a single assay

80+

Compatible with 80+ assays

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SP-X Imaging and Analysis System™ tab thumbnail

SP-X Imaging and Analysis System™

Unleashing the power of next-generation Simoa® Planar Array technology for robust multiplex biomarker detection – even at healthy baseline levels.

SP-X Imaging and Analysis System™ tab thumbnail

1000x

Up to 1000x greater sensitivity

10 in 1

Up to 10 biomarkers in a single assay

100+

Compatible with 100+ assays

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SR-X™ Biomarker Detection System

Offers researchers access to ultra-sensitive biomarker detection capabilities in a compact and affordable system.

SR-X™ Biomarker Detection System tab thumbnail

1000x

Up to 1000x greater sensitivity

4 in 1

Up to 4 biomarkers in a single assay

30+

Compatible with 30+ assays

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Ready to take your biomarker research to the next level?

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Simoa® Accelerator Laboratory

With the Simoa® Accelerator Laboratory as your pharma service technology solution of choice, you can expand the limits of biomarker exploration and dramatically accelerate the timeline to drug approvals.

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